1. Programming is dead. There were basically zero programming talks at GDC this year. That's sad, but also perfectly reasonable since programming is not the problem any more (*). (* = assuming that you just want to make the same old shit with different graphics)
2. Piece of shit mobile games that people have thrown together in a month look better than AAA games 10 years ago. It's not just that GPU's are so much better, but the free engines are really amazing these days, and the content pipes are so much better, and there are so many more decent 3d artists that can just make tons of content.
3. Game developers look like human beings now. If you looked at a GDC when I first started going, we were all classic troglodyte nerds; unwashed sweatshirts and open backpacks with slide-rules falling out. We were all vampirically pale from being locked in a dark box surrounded by our giant CRTs. (more generally I'm noticing that the average fitness level (on the west coast anyway) is way up in the past 5 years or so).
4. Mobile is dead, downloadable is king. I do an unscientific random sampling every year just by asking the people who stop by the RAD booth what they're working on. For the past few years it has been mobile mobile "we're making a game for ios and android", tons of kids and startups and indies trying to get into mobile. That seems to be gone, and the new gold rush is "downloadable" (PC, XBLA, etc).
5. Games are tacky and tasteless. One of the worst things for me standing at the booth is just hearing and seeing games all day. I don't play games much, I never watch TV with commercials, and I never watch things like cable news with all the excessive HUD and overstimulation, I find all that stuff abusive of my senses. Games are stuck in this awful "bling bling whoosh blammo" flashing and fast-cuts and just really tacky aesthetic. It's just like TV ads, or a bit like standing in the slot machine section of a casino (which is surely some level of hell).
6. I saw one really amazing game at GDC that stood out from the rest. It had all the players instantly smiling and laughing. It was fun for kids and adults. It created a feeling of group affinity. Everyone around wanted to join in. It was even beneficial to the body. It was an inflatable ball. Personally I had the "holy shit what we make is total crap" (actually worse than crap, because it's actively harmful to the body and mind) epiphany some 10+ years ago, but it just struck me so hard standing there with all these shit games around and people having so much more fun in the most basic game in the non-electronic world.